Mitochondrial health influences clarity, focus, metabolism, stamina, and even sleep quality. When mitochondria slow down, you feel it across your entire day. One compound that continues to stand out for supporting these foundational pathways is methylene blue.

For the complete deep dive with all the nuance and detail, listen to Episode #594: “Beyond the Hype — A Practical Guide to Methylene Blue and Brain Energy.”

As methylene blue has gained popularity, one of the biggest challenges has become purity. I’ve been approached by companies wanting me to carry their version, and the moment I ask for real testing or documentation, things fall apart. With a compound this potent, transparency matters. That’s why the only methylene blue I carry is from Best365 Labs. Their sourcing, testing, and formulation work are consistent, rigorous, and trustworthy.

Below is a concise guide to how methylene blue works and how to choose the formulas or stacks that make the most sense for your goals.

How Methylene Blue Supports Mitochondria

Methylene blue helps electrons move more efficiently through the electron transport chain. This supports ATP production and a healthy redox balance. Many people report improvements in clarity, focus, mental stamina, and smooth physical energy. It’s not a stimulant—it simply helps the system function the way it's built to function.

A Quick Look at the Best365 Formulas

NeuroPro Plus

A high-potency methylene blue formula combined with vitamin C for clean, steady mitochondrial and cognitive support.

NeuroPro Memory

Designed for people wanting support for short-term and long-term memory. Includes glycine, NAC, niacinamide, and methylene blue.

Metabolism+

A calm, balanced energy formula with L-theanine, natural caffeine sources, and a low dose of methylene blue.

ADHD-365

A stronger focus formula containing higher caffeine paired with high L-theanine and methylene blue for people needing more pronounced focus support.

Brain Fog Liquid

A fast-absorbing methylene blue liquid with vitamin C and a mineral complex. This is the easiest and most economical entry point.

Activate/Restore/Mito365 Kit

This three-part system is often used and recommended by Best365 as a bundle. It is designed for daytime mitochondrial activation and nighttime cellular recovery. Best365 Labs considers this combination their ultimate mitochondrial optimization toolkit. It is best used as a single system, with the option to add creatine if desired.

Why These Additional Products Pair Well

Creatine

Supports ATP recycling and cellular energy output, making it one of the most logical additions to any methylene blue stack.

Vital NMN (optional add-on)

Supports NAD production, an essential component of mitochondrial efficiency and cellular repair.

MindFuel

Provides energized, uplifted focus. Ideal for people who want motivation, productivity, and mental drive alongside methylene blue.

Liquid Yoga

Supports calmer, stress-balanced focus. Ideal for people who want improved clarity without additional stimulation. MindFuel and Liquid Yoga are typically an either/or choice depending on whether you want energized focus or calm focus.

STACKS

My Personal Approach

For my own brain chemistry, a half-dose of ADHD-365 combined with one tablet of NeuroPro Plus works extremely well. I take creatine every day, and it has been part of my foundational routine for a couple of years now. Recently, I’ve been experimenting with MindFuel—both on its own and alongside the methylene blue formulas—to fine-tune mental energy and focus. I strongly encourage you to experiment and find your own sweet spot. Every nervous system responds differently, and the best results come from thoughtful adjustments.

STACK 1: Mitochondrial Energy & Metabolic Support

• Mito365

• NeuroPro Plus

• Creatine
  Optional add-on: Vital NMN

This combination supports clearer thinking, steadier daytime energy, and foundational mitochondrial function.

STACK 2: Focus & Attention

• Metabolism+

• NeuroPro Plus

• MindFuel or Liquid Yoga

Choose MindFuel for energized, driven focus.
Choose Liquid Yoga for calm, steady focus without overstimulation.

STACK 3: Memory Support

• NeuroPro Memory

• Metabolism+

• MindFuel or Liquid Yoga

STACK 4: Cellular Regeneration & Sleep Repair

Use the Activate/Restore/Mito365 Kit as a complete system.
Creatine may be added for deeper mitochondrial support.

Finding Your Dose

Some people respond exceptionally well to very small amounts of methylene blue. It is wise to start low and adjust upward only if needed. Adding or removing supporting formulas based on how you feel is not only appropriate—it’s recommended. The goal is to find the level and combination that aligns with your energy, focus, and recovery needs.

December Promotion

Through December 31st:

• Buy any two methylene-blue-related products and receive 20% off

• Buy any three or more and receive 30% off

This includes Vital NMN, MindFuel, Liquid Yoga, and all Best365 MB formulas. No code is required—discounts apply automatically.

Final Word

Methylene blue is not a magic pill, but it is one of the most compelling tools available for supporting mitochondrial function, mental clarity, metabolic vitality, and long-term cellular resilience. When combined with clean sourcing, intelligent formulation, and personal experimentation, it becomes a powerful ally in your daily wellness strategy.

Stay consistent. Stay curious. And stay vital.